Antiepileptic Drugs and Pregnancy by MJ Eadie & FJE Vajda

Author:MJ Eadie & FJE Vajda
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Effects on the Foetus

It might be anticipated that the violent physical activity entailed in a generalised convulsive seizure in a pregnant woman, and the associated circulatory alterations and hypoxia, could damage the foetus she was carrying. Yerby (2008) took the view that generalised tonic–clonic seizures increased the risk of hypoxaemia, acidosis and injury from birth trauma and also the likelihood of stillbirth but then stated that such events rarely arose as consequences of seizures. There has been a report of foetal heart slowing during a maternal convulsive seizure (Teramo et al. 1979), and there have also been suggestions that foetal malformation may result from intrauterine hypoxia . But have these predictions been borne out in clinical practice?

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